(CNN) -- It sounds like something from the movie "Twister" -- teams of scientists in vans, armed with high-tech measuring equipment, barreling across the Oklahoma plains in search of tornadoes.

But these scientists are colleagues, not rivals, and these storms aren't Hollywood digital wizardry but the real thing.

Welcome to VORTEX2, or V2 for short, the largest and most ambitious field experiment ever devoted to studying tornadoes. Now under way through June 13 in Oklahoma and surrounding states, the project brings together almost 100 scientists and students from 16 universities and research institutes.

VORTEX2 kicked off Sunday, and its teams didn't have to wait long to find the targets of their research. Violent storms tore through four Midwestern states Wednesday, killing three people in northern Missouri, according to Kansas City affiliate KMBC. The storms damaged dozens of homes and left thousands without power.

The storm chasers of VORTEX2 -- Verification of the Origins of Rotation in Tornadoes Experiment 2 -- try to learn how and when tornadoes form, and why some thunderstorms produce tornadoes while others do not. Researchers hope the answers to these questions will help increase warning times for those in the path of these deadly twisters.

"Data collected from V2 will help researchers understand how tornadoes form and how the large-scale environment of thunderstorms is related to tornado formation," said Louis Wicker, research meteorologist with the National Oceanic and Atmospheric Administration.

V2 is a $11.9 million program funded by NOAA and the National Science Foundation, 10 universities and three non-profit organizations.

The project is a successor to the original VORTEX field program, in 1994 and 1995, that documented the entire life cycle of a tornado for the first time in history. The research helped improve tornado warnings by the National Weather Service during the late 1990s.

"An important finding from the original VORTEX experiment was that the factors responsible for causing tornadoes happen on smaller time and space scales than scientists had thought," said Stephan Nelson, NSF program director for physical and dynamic meteorology.

"New advances will allow for a more detailed sampling of a storm's wind, temperature and moisture environment and lead to a better understanding of why tornadoes form and how they can be more accurately predicted," he said. 10 deadliest U.S. tornadoes »

Researchers will present preliminary results from V2 this fall at Penn State University. At that time, organizers also will begin planning details of the second phase of V2, scheduled for May 1- June 15, 2010.

This spring's V2 teams are chasing supercells -- violent thunderstorms capable of producing damaging winds, large hail and tornadoes -- that typically form over more than 900 miles of the central Great Plains, from South Dakota to the Texas panhandle and from eastern Colorado to western Missouri.

The researchers try to locate these explosive storms and surround them with an armada of high-tech instruments, such as radar, weather balloons, barometers and computer programs, to gain a three-dimensional picture of how the storms form and mutate.

"Each of these vehicles has a specific position in the storm," said storm chaser Harald Richter of the Bureau of Meteorology Training Centre in Melbourne, Australia. "Our mission is to come in from the west, get close to the tornado -- not too close -- turn around, head back out west and penetrate a feature that we call the 'hook echo.' " See the number of tornadoes the U.S. averages per month »

A hook echo is a secondary, curving storm pattern that shows up on radar, wrapped around a larger storm.

"The big mystery is the concentrated rotation of the tornado itself. Where does that come from?" University of Oklahoma graduate student Owen Shieh told CNN. "Does it come from the temperature differences, the buoyancy differences between the cold air and the warm air inside the super cell? Exactly how that works, we don't know."

The scientists and students of V2 hope that by improving their understanding of tornado formation, they will be able to help forecasters alert residents more quickly -- in time to keep them safe.
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Thanks to "Twister" and programs like the Discovery Channel's "Storm Chasers" -- also filming episodes with the V2 teams this week -- studying tornadoes is seen by many as a thrilling science. But V2 participants are quick to discourage anyone from trying to do what they do.

"And there shall be signs in the sun, and in the moon, and in the stars; and upon the earth distress of nations, with perplexity; the sea and the waves roaring;" Luk 21:25